2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates
  5. Cereblon Isoform

Cereblon

 

Cereblon Related Products (429):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112599B
    Pomalidomide-PEG4-C2-NH2 hydrochloride 2357105-92-9 98.18%
    Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs..
    Pomalidomide-PEG4-C2-NH2 hydrochloride
  • HY-141012
    Thalidomide-O-PEG4-NHS ester 2411681-88-2 98.76%
    Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thalidomide-O-PEG4-NHS ester
  • HY-137538
    Pomalidomide-PEG3-azide 2267306-15-8 98.48%
    Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pomalidomide-PEG3-azide
  • HY-21930
    Pomalidomide-PEG4-C-COOH 2097938-44-6 99.19%
    Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
    Pomalidomide-PEG4-C-COOH
  • HY-125843
    Pomalidomide-PEG1-C2-N3 2271036-44-1 99.91%
    Pomalidomide-PEG1-C2-N3 (Cereblon Ligand-Linker Conjugates 13) is a cereblon E3 ligand-linker conjugate that can be used to synthesisi selective CDK6 PROTAC degrader CP-10 (HY-125835). Pomalidomide-PEG1-C2-N3 can be used for the research of cancers.
    Pomalidomide-PEG1-C2-N3
  • HY-122725
    Lenalidomide-C5-NH2 2093388-45-3 98.45%
    Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2.
    Lenalidomide-C5-NH2
  • HY-179096
    E3 Ligase Ligand-linker Conjugate 213 1334496-37-5
    E3 Ligase Ligand-linker Conjugate 213 is an E3 ligase ligand-linker conjugate (E3 ligase ligand-linker conjugate) consisting of an E3 ubiquitinase CRBN ligand (HY-A0003) and a linker (HY-W008820). E3 Ligase Ligand-linker Conjugate 213 can be used to synthesize PSP-0119 (HY-179094).
    E3 Ligase Ligand-linker Conjugate 213
  • HY-182890
    Thalidomide-5-NH-C9-acid 2473267-89-7
    Thalidomide-5-NH-C9-acid is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based Cereblon ligand and one linker.
    Thalidomide-5-NH-C9-acid
  • HY-129703B
    Thalidomide-PEG2-C2-NH2 hydrochloride 2245697-87-2 99.93%
    Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
    Thalidomide-PEG2-C2-NH2 hydrochloride
  • HY-141015
    Pomalidomide-PEG4-azide 2271036-47-4 99.85%
    Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pomalidomide-PEG4-azide
  • HY-141011
    Thalidomide-O-amido-PEG4-azide 2411681-89-3 99.19%
    Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Thalidomide-O-amido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Thalidomide-O-amido-PEG4-azide
  • HY-122725B
    Lenalidomide-C5-NH2 hydrochloride 2595367-27-2 99.28%
    Lenalidomide-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 hydrochloride can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2.
    Lenalidomide-C5-NH2 hydrochloride
  • HY-130652
    Pomalidomide 4'-PEG3-azide 2271036-46-3
    Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pomalidomide 4'-PEG3-azide
  • HY-126457
    Thalidomide-propargyl 2098487-39-7 99.97%
    Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs. Thalidomide-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Thalidomide-propargyl
  • HY-115446A
    Lenalidomide-C4-NH2 hydrochloride 2435715-90-3
    Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively.
    Lenalidomide-C4-NH2 hydrochloride
  • HY-135250B
    Thalidomide-4-O-C6-NH2 hydrochloride 2245697-88-3 98.53%
    Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET.
    Thalidomide-4-O-C6-NH2 hydrochloride
  • HY-46531
    Thalidomide-5-NH2-CH2-COOH 2412056-27-8
    Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for researching one or more diseases (extracted from patent WO2021170109A1).
    Thalidomide-5-NH2-CH2-COOH
  • HY-136237
    Thalidomide-NH-C5-NH2 hydrochloride 2375194-03-7 99.86%
    Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-NH-C5-NH2 hydrochloride
  • HY-148142
    Pomalidomide-C3-NHS ester 2828476-87-3 98.70%
    Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker.
    Pomalidomide-C3-NHS ester
  • HY-140844
    Thalidomide-O-PEG4-azide 2380318-57-8 98.02%
    Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Thalidomide-O-PEG4-azide